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M3-Emerging Medical Research

EmergeOrtho and Wake Research Associates have combined to form “M3-Emerging Medical Research.” To read more about this new endeavor, view our Press Release here.


Help move COVID-19 research forward by enrolling in a paid vaccine research study at Wake Research. Qualified applicants will be compensated up to $1800 for their participation in this study.

To qualify, you must:

  • Be 18+ years old
  • At high risk for getting COVID-19

Click for more information and to sign up!

What is Clinical Research?

The physicians and research staff at EmergeOrtho have many years of experience performing research from advanced devices for spine surgery to the latest biotech pharmaceuticals. Currently, our clinical research and trials are only available in the Triangle region. We assist local universities as well as national networks of researchers in learning more about the causes of different forms of arthritis. We have participated in clinical trials of most of the rheumatoid arthritis and psoriatic arthritis medications that have become available over the past 20 years including Enbrel, Humira, Orencia, Rituxan, Kineret, Actemra, Xelganz, Cosentyx, and Cimzia as well as the major anti-inflammatory medications. In addition to rheumatoid arthritis, our studies have included research on gout, pain, osteoarthritis, and various types of back and neck arthritis and disc disease. At EmergeOrtho, we believe the availability of clinical research is a major resource for our patients allowing them access to cutting edge therapies when established medications and procedures are not satisfactory. Our participation also keeps us at the forefront of the newest advances. Please check our site often or contact us if you are interested in possible participation in a clinical trial. We are frequently starting new research projects.

Clinical Research Projects

Currently Enrolling Clinical Trials (trials are only available in the Triangle region)

If you would like to know more about any of our current research programs or clinical trials in the Triangle region, please contact our clinical research department at 919-281-1698 or by email at sparker@wakeresearch.com.

Rheumatoid Arthritis Clinical Trials

We are always conducting several studies of new treatments for rheumatoid arthritis. If you would like to consider participating, please contact us to see if we have a study that fits your needs.

Spine Disease Clinical Trials

We are involved in several studies of new therapies for various kinds of spine disease. If you are interested in participating in a study, please contact us.

Centinel Spine Clinical Study for Total Disc Replacement for 2-Level Symptomatic Cervical Disc Disease

  • Emerging Medical Research, Dr. David Musante, began enrolling for a clinical trial featuring two artificial cervical discs from Centinel Spine. The study will compare the prodisc® C Vivo and prodisc® C SK cervical discs with the FDA approved Mobi-C®. The randomized clinical trial is enrolling patients with neck and arm pain who have not had a previous cervical spine surgery. The Mobi-C device will be used as a control to determine the safety and efficacy of the prodisc C discs to treat cervical disc disease in patients unresponsive to nonoperative treatment at two levels. The study is taking place across the US. For more information about this study, visit ClinicalTrials.gov (Identifier NCT04012996). Click here to sign up!

Learn more about the Centinel Spine clinical trial featuring two artificial cervical discs. 

Psoriatic Arthritis Clinical Trials

We are always conducting several studies of new treatments for psoriatic arthritis. If you would like to consider participating, please contact us to see if we have a study that fits your needs.

Please contact us if you would like more information about these or future clinical trials (trials are only available in the Triangle region at this time).

Clinical Trials FAQ

Since 2018, EmergeOrtho has partnered with Wake Research as Emerging Medical Research to bring patients access to the latest in orthopedic research and clinical trials.

Many patients who have never participated in clinical research may have questions about how clinical research and clinical trials work. Here are the most frequently asked questions about clinical trials:

What are clinical trials?

Clinical trials are the most important part of all medical advancements and research. They are designed to test and study the safety and effectiveness of investigational medications and treatments. Clinical trials study different things – some trials look at new treatments for chronic diseases and conditions (like a medical device or a drug), while some trials test ways to diagnose diseases early or possibly prevent them.

Why are clinical trials important?

Clinical trials are an essential part of making sure the drugs and medical treatments we all use are safe and effective. They are also extremely important in finding new and better treatments and in helping make life more comfortable for people with chronic diseases.

“Before your doctor can write you a prescription and your treatments are available at your pharmacy, every drug must go through clinical trials to demonstrate it is safe and effective, compared to a placebo or to existing therapies,” Dr. Marieke Cajal-Berman, director of patient engagement for Wake Research, said.

“Clinical trials are conducted to measure how well a medication or therapy performs when used to treat a certain condition,” she said. They could be testing a drug for a condition that currently does not have any available treatment, or testing a drug that might work better than currently available treatments or have less side effects.”

Who can participate in clinical trials?

People who have a disease or other chronic medical condition can participate in clinical trials, as well as healthy individuals looking to help contribute to research.

People participate in clinical trials for different reasons. Some people participate to try a new treatment when existing therapies haven’t worked, or if there is no existing treatment for their condition. Other people who are healthy might participate to help advance research of diseases they may have in their genetics or just be a part of discovering new treatments.

“Some volunteers participate to better understand their conditions through the tests offered at no cost as part of the trial, to try new treatments when they cannot tolerate or afford current ones, or to help advance research for other patients with the same condition and future patients,” Dr. Cajal-Berman said.

Should you participate in a clinical trial?

Clinical trials could not exist without volunteers, and there are many benefits to participating in a clinical trial. Participants in clinical trials play an active role in their own health care; they gain access to cutting-edge research treatments before they are available to the general public, and by participating they help contribute to the development of new and important treatments.

“Progress in medicine cannot happen without the help and participation of our volunteers,” Dr. Cajal-Berman said. “Patients are also compensated for their time and travel and accompanied by a doctor through the whole process.

But before participating in a clinical trial, you will need to qualify. There are often specific criteria for meeting the qualifications of a clinical trial. If you decide to apply to a clinical trial, you will be asked a series of questions in a pre-screening interview. Sometimes, a second screening will take place to make sure you meet the qualifications for the trial. If you do, then you will be able to be a part of the trial.

What is the current work being done in clinical trials?

There is a lot of very important research currently being done in clinical trials. Some of the conditions and treatments being studied are:

  • Drug treatments and genetic biomarker studies for long term diseases
  • Vaccinations and drugs for COVID-19
  • Immunotherapy treatment for cancer and other diseases

Orthopedic conditions currently being studied are:

  • Osteoarthritis
  • Rheumatoid arthritis
  • Psoriasis
  • Gout

Every single drug and treatment used in healthcare today was first tested through a clinical trial. Clinical trials help ensure drugs and treatments are safe, effective, and can better the lives of individuals who are suffering from diseases now and in the future.

To view the currently enrolling studies at Emerging Medical Research and Wake Research, visit https://www.wakeclinical.com/studies/.

Meet Our Clinical Research Staff

Linda Belhorn, M.D.
Director of Clinical Research

Jan Hallenborg. L.P.N.
Clinical Research Coordinator

Shandelle Parker, CCRC
Certified Clinical Research Coordinator

David Musante, MD FAAOS
Medical Director Emerging Medical Research

Sara Monday
Site Development Director

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