James C. Karegeannes, MD
James C. Karegeannes, MD

Joint Replacement

Board Certified in Orthopedic Surgery

Blue Ridge Region

Asheville - McDowell

Meet Dr. James C. Karegeannes

Dr. James C. Karegeannes [Care-ah-gene-us] graduated magna cum laude from the University of South Carolina Honors Program. In addition to being named a National Merit Scholar, he was also a member of Phi Beta Kappa. He completed medical school at Duke University. Dr. Karegeannes completed his internship at the San Diego Naval Hospital. This was followed by three years as a Submarine and Diving Medical Officer in the Navy. He then returned to Duke for his Orthopedic Surgery Training followed by a Hip and Knee Replacement Fellowship at The Hospital for Special Surgery in New York City.

He specializes in hip and knee replacement surgery, as well as revision surgery for failed replacements. He performs more than 450 joint replacement surgeries per year. He was named one of the “Top Doctors” for Hip and Knee Arthroplasty, Money magazine, Special Report, “The Best Health Care in America”, in fall 2003. He reviews articles the Journal of Arthroplasty and cases for the North Carolina Medical Board. He is currently the chief of the Orthopedic service line at Mission HCA hospital in Asheville.

He is active in local and national joint replacement organizations to help ensure that patients in our region can access the latest treatment options. He does not accept consulting fees or other payments from joint implant manufacturers to ensure his recommendations for treatment are unbiased and place his patients’ interests first.

Outside the office, he enjoys spending time with his wife, two adult children and one large hound dog. He serves on the local Boy Scout council executive board, enjoys hiking, gardening and burrowing into old books on food and drink culture.


  • Undergraduate: University of South Carolina, Columbia
  • Medical School: Duke University School of Medicine
  • Internship: Naval Medical Center San Diego
  • Residency: Duke Health, Durham
  • Fellowship:
    • Carolina Orthopedic Center, Greenville, South Carolina
    • The Hospital for Special Surgery, New York, New York


  • “Top Doctors” for Hip and Knee Arthroplasty, Money magazine, Special Report, “The Best Health Care in America”, Fall 2003
  • Navy Commendation Medal, United States Navy, 1993
  • Navy Achievement Medal, United States Navy, 1991
  • Health Professions Scholarship, United States Navy, 1986 – 1989
  • Outstanding Seniors Award, University of South Carolina, 1985
  • Phi Beta Kappa, 1984
  • University of South Carolina General Scholarship, 1981 – 1985
  • University of South Carolina Alumni Association Scholarship, 1981 – 1985
  • National Merit Scholar, 1981 – 1985


  • American Association of Hip and Knee Surgeons
  • American Medical Association
  • American Academy of Orthopedic Surgery
  • North Carolina Orthopedic Association
  • Piedmont Orthopedic Association

Specialties & Services

Dr. Karegeannes is a great physician. He made me feel comfortable and less nervous about my upcoming surgery.

Michael M


Dr. K. was kind, sincere, and totally competent. He told me before my hip replacement that I would be able to do about anything I want to do after the surgery, and he was right. I couldn't be more pleased.

Jane Y


A New Level Of Orthopedic Care Has Emerged

As our patient, you will benefit from a full range of orthopedic services, specialties and technologies, including physical and hand therapy, advanced imaging services, and urgent care walk-in services providing immediate diagnosis and treatment for urgent orthopedic conditions.