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James C. Karegeannes, MD

James C. Karegeannes, MD

Joint Replacement

Board Certified in Orthopedic Surgery

Blue Ridge Region

Asheville - McDowell

Dr. James C. Karegeannes [Care-ah-gene-us] graduated magna cum laude from the University of South Carolina. In addition to being named a National Merit Scholar, he was also a member of Phi Beta Kappa. He completed both his medical degree and residency at Duke University. Dr. Karegeannes also completed an internship at the San Diego Naval Hospital and an Adult Reconstruction Fellowship at The Hospital for Special Surgery in New York, NY.

He not only specializes in hip and knee replacement surgery, but he also conducts revision surgery for failed replacements, performing more than 450 joint replacements a year. He was named one of the “Top Doctors” for Hip and Knee Arthroplasty, Money magazine, Special Report, “The Best Health Care in America”, in fall 2003.

He wants to ensure that patients in our region can easily access the latest treatment options and therefore, he’s active in local and national joint replacement organizations. He also reviews articles for publication in professional medical journals.

Outside the office, he spends time with his wife, two children and two dogs. He’s an Assistant Scoutmaster with Boy Scout Troop 91 in Asheville, and he serves in various other volunteer roles for the local Scout Council. He has had to call on his orthopedic training to help sustain himself as he resumes backpacking after a 30-year break.

He does not accept consulting fees or other payments from joint implant manufactures.

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  • Undergraduate: University of South Carolina, Columbia
  • Medical School: Duke University School of Medicine
  • Internship: Naval Medical Center San Diego
  • Residency: Duke Health, Durham
  • Fellowship:
    • Carolina Orthopedic Center, Greenville, South Carolina
    • The Hospital for Special Surgery, New York, New York


  • “Top Doctors” for Hip and Knee Arthroplasty, Money magazine, Special Report, “The Best Health Care in America”, Fall 2003
  • Navy Commendation Medal, United States Navy, 1993
  • Navy Achievement Medal, United States Navy, 1991
  • Health Professions Scholarship, United States Navy, 1986 – 1989
  • Outstanding Seniors Award, University of South Carolina, 1985
  • Phi Beta Kappa, 1984
  • University of South Carolina General Scholarship, 1981 – 1985
  • University of South Carolina Alumni Association Scholarship, 1981 – 1985
  • National Merit Scholar, 1981 – 1985


  • American Association of Hip and Knee Surgeons
  • American Medical Association
  • American Academy of Orthopedic Surgery
  • North Carolina Orthopedic Association
  • Piedmont Orthopedic Association

Specialties & Services

Dr. Karegeannes is an excellent doctor! I'm so thankful that my referral was with him. After a hard 2 years of pain & the many types of providers I went to looking for answers...Dr. Karegeannes knew from the start that the pain was my hip joints and his surgeries were spot on perfect! Two hips in 6 months and I'm a happy camper!

Pamela U


Dr. K. was kind, sincere, and totally competent. He told me before my hip replacement that I would be able to do about anything I want to do after the surgery, and he was right. I couldn't be more pleased.

Jane Y


A New Level Of Orthopedic Care Has Emerged

As our patient, you will benefit from a full range of orthopedic services, specialties and technologies, including physical and occupational therapy, advanced imaging services, and urgent care walk-in services providing immediate diagnosis and treatment for urgent orthopedic conditions.

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